Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.febslet.2013.10.025
Title: | Tapping the treasure of intracellular oncotargets with immunotherapy | Authors: | Hong, C.W. Zeng, Q. |
Keywords: | Antibody therapy Cancer Extracellular receptor Immunotherapy Intracellular oncotarget Vaccination |
Issue Date: | 21-Jan-2014 | Citation: | Hong, C.W., Zeng, Q. (2014-01-21). Tapping the treasure of intracellular oncotargets with immunotherapy. FEBS Letters 588 (2) : 350-355. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2013.10.025 | Abstract: | It is commonly believed that antibodies are too large (∼150 kDa) to access the intracellular compartment. Therefore, therapeutic antibodies have been traditionally used to target cell surface receptors or soluble proteins in the circulation, leaving a large intracellular treasure of potential cancer-specific targets untapped. This review offers new perspectives on our recently proposed concept that antibodies can be used to target intracellular tumor antigens for anti-cancer therapy. We propose to vastly expand the repertoire of potential targets for cancer immunotherapy since many excellent cancer targets are inside cells. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | Source Title: | FEBS Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/117358 | ISSN: | 00145793 | DOI: | 10.1016/j.febslet.2013.10.025 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.