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|Title:||Tapping the treasure of intracellular oncotargets with immunotherapy|
|Source:||Hong, C.W., Zeng, Q. (2014-01-21). Tapping the treasure of intracellular oncotargets with immunotherapy. FEBS Letters 588 (2) : 350-355. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2013.10.025|
|Abstract:||It is commonly believed that antibodies are too large (∼150 kDa) to access the intracellular compartment. Therefore, therapeutic antibodies have been traditionally used to target cell surface receptors or soluble proteins in the circulation, leaving a large intracellular treasure of potential cancer-specific targets untapped. This review offers new perspectives on our recently proposed concept that antibodies can be used to target intracellular tumor antigens for anti-cancer therapy. We propose to vastly expand the repertoire of potential targets for cancer immunotherapy since many excellent cancer targets are inside cells. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.|
|Source Title:||FEBS Letters|
|Appears in Collections:||Staff Publications|
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