Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2013.10.025
Title: Tapping the treasure of intracellular oncotargets with immunotherapy
Authors: Hong, C.W.
Zeng, Q. 
Keywords: Antibody therapy
Cancer
Extracellular receptor
Immunotherapy
Intracellular oncotarget
Vaccination
Issue Date: 21-Jan-2014
Citation: Hong, C.W., Zeng, Q. (2014-01-21). Tapping the treasure of intracellular oncotargets with immunotherapy. FEBS Letters 588 (2) : 350-355. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2013.10.025
Abstract: It is commonly believed that antibodies are too large (∼150 kDa) to access the intracellular compartment. Therefore, therapeutic antibodies have been traditionally used to target cell surface receptors or soluble proteins in the circulation, leaving a large intracellular treasure of potential cancer-specific targets untapped. This review offers new perspectives on our recently proposed concept that antibodies can be used to target intracellular tumor antigens for anti-cancer therapy. We propose to vastly expand the repertoire of potential targets for cancer immunotherapy since many excellent cancer targets are inside cells. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/117358
ISSN: 00145793
DOI: 10.1016/j.febslet.2013.10.025
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