Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cell.2009.11.007
Title: Epithelial-Mesenchymal Transitions in Development and Disease
Authors: Thiery, J.P. 
Acloque, H.
Huang, R.Y.J.
Nieto, M.A.
Issue Date: 25-Nov-2009
Citation: Thiery, J.P., Acloque, H., Huang, R.Y.J., Nieto, M.A. (2009-11-25). Epithelial-Mesenchymal Transitions in Development and Disease. Cell 139 (5) : 871-890. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cell.2009.11.007
Abstract: The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis. © 2009 Elsevier Inc. All rights reserved.
Source Title: Cell
URI: http://scholarbank.nus.edu.sg/handle/10635/117346
ISSN: 00928674
DOI: 10.1016/j.cell.2009.11.007
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