Please use this identifier to cite or link to this item: https://doi.org/10.1242/jcs.126367
Title: Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1
Authors: Zhou, W.
Thiery, J.P. 
Keywords: EMT
Git2
MiR-146a
Zeb1
Issue Date: Jun-2013
Citation: Zhou, W., Thiery, J.P. (2013-06). Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1. Journal of Cell Science 126 (12) : 2740-2746. ScholarBank@NUS Repository. https://doi.org/10.1242/jcs.126367
Abstract: Epithelial-mesenchymal transition (EMT) can be induced by several pleiotropically activated transcription factors, including the zincfinger E-box-binding protein Zeb1. Mechanisms regulating Zeb1 expression have been partly uncovered, showing a critical role for the miR-200 family members. In the present study, we show that Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2. Following the loss of Git2, we found that miR-146a maturation is enhanced, which in turn promotes the expression of Zeb1 and induction of EMT. Furthermore, we found that Cnot6L, a validated target of miR-146a, affects the stability of Zeb1 mRNA through its deadenylase activity. Our results present evidence for a new role for loss of Git2 in promoting EMT through a novel regulatory pathway. © 2013. Published by The Company of Biologists Ltd.
Source Title: Journal of Cell Science
URI: http://scholarbank.nus.edu.sg/handle/10635/117065
ISSN: 00219533
DOI: 10.1242/jcs.126367
Appears in Collections:Staff Publications

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