Please use this identifier to cite or link to this item:
|Title:||Translating metastasis-related biomarkers to the clinic - Progress and pitfalls|
|Citation:||Bidard, F.-C., Pierga, J.-Y., Soria, J.-C., Thiery, J.P. (2013-03). Translating metastasis-related biomarkers to the clinic - Progress and pitfalls. Nature Reviews Clinical Oncology 10 (3) : 169-179. ScholarBank@NUS Repository. https://doi.org/10.1038/nrclinonc.2013.4|
|Abstract:||In the context of metastatic disease, preclinical models have been used primarily to decipher different steps of the metastatic cascade. Numerous molecular processes operate in these model systems, but none of these has been successfully translated to the clinic. We discuss some of the successes and failures of preclinical models in metastasis research and suggest some of the clues for more clinically relevant research. These potential avenues of research include: the use of adequate statistical methods and well-annotated cohorts in biomarker discovery; an objective assessment of the level of evidence provided by each biomarker; the development of robust molecular or cellular surrogates of metastasis in patients; and original designs for clinical trials. © 2013 Macmillan Publishers Limited. All rights reserved.|
|Source Title:||Nature Reviews Clinical Oncology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 16, 2018
WEB OF SCIENCETM
checked on Oct 31, 2018
checked on Aug 31, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.