Please use this identifier to cite or link to this item: https://doi.org/10.1586/era.12.17
Title: ROS1 as a 'druggable' receptor tyrosine kinase: Lessons learned from inhibiting the ALK pathway
Authors: Ou, S.-H.I.
Tan, J.
Yen, Y.
Soo, R.A. 
Keywords: ALK inhibitor
CD74-ROS1
cholangiocarcinoma
crizotinib
driver mutation
FIG-ROS1
glioblastoma multiforme
non-small-cell lung cancer
personalized medicine
ROS1 inhibitor
ROS1 receptor tyrosine kinase
SLC34A2-ROS1
Issue Date: Apr-2012
Citation: Ou, S.-H.I., Tan, J., Yen, Y., Soo, R.A. (2012-04). ROS1 as a 'druggable' receptor tyrosine kinase: Lessons learned from inhibiting the ALK pathway. Expert Review of Anticancer Therapy 12 (4) : 447-456. ScholarBank@NUS Repository. https://doi.org/10.1586/era.12.17
Abstract: ROS1 is one of 58 receptor tyrosine kinases, and one of two orphan receptor tyrosine kinases where its ligand is unknown. ROS1 is evolutionarily related to ALK. ROS1 rearrangement was discovered in glioblastoma in 1987, in non-small-cell lung cancer (NSCLC) in 2007, and in cholangiocarcinoma in 2011. While the clinicopathologic characteristics of ROS1-rearranged glioblastoma and cholangiocarcinoma patients remain to be defined, the clinicopathologic characteristics of ROS1-rearranged NSCLC patients have recently been described. Although ROS1 shares only 49% amino acid sequence homology with ALK in the kinase domains, several ALK inhibitors have demonstrated in vitro inhibitory activity against ROS1. With the recent US approval of crizotinib, a multi-targeted ALK/MET kinase inhibitor, for the treatment of ALK-rearranged NSCLC, attention has turned to ROS1-rearranged tumors, especially NSCLC. The next few years should witness a rapid pace of clinical research in ROS1-rearranged tumors utilizing available ALK inhibitors. © 2012 Expert Reviews Ltd.
Source Title: Expert Review of Anticancer Therapy
URI: http://scholarbank.nus.edu.sg/handle/10635/116889
ISSN: 14737140
DOI: 10.1586/era.12.17
Appears in Collections:Staff Publications

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