Lipidomic "deep profiling": An enhanced workflow to reveal new molecular species of signaling lipids

Please use this identifier to cite or link to this item: https://doi.org/10.1021/ac4039652

Title:	Lipidomic "deep profiling": An enhanced workflow to reveal new molecular species of signaling lipids
Authors:	Narayanaswamy, P. Shinde, S. Sulc, R. Kraut, R. Staples, G. Thiam, C.H. Grimm, R. Sellergren, B. Torta, F. Wenk, M.R.
Issue Date:	2014
Citation:	Narayanaswamy, P., Shinde, S., Sulc, R., Kraut, R., Staples, G., Thiam, C.H., Grimm, R., Sellergren, B., Torta, F., Wenk, M.R. (2014). Lipidomic "deep profiling": An enhanced workflow to reveal new molecular species of signaling lipids. Analytical Chemistry 86 (6) : 3043-3047. ScholarBank@NUS Repository. https://doi.org/10.1021/ac4039652
Abstract:	Current mass spectrometry-based lipidomics aims to comprehensively cover wide ranges of lipid classes. We introduce a strategy to capture phospho-monoester lipids and improve the detection of long-chain base phosphates (LCB-Ps, e.g., sphingosine-1-phosphate). Ten novel LCB-Ps (d18:2, t20:1, odd carbon forms) were discovered and characterized in tissues from human and mouse, as well in D. melanogaster and S. cerevisiae. These findings have immediate relevance for our understanding of sphingosine-1-phosphate biosynthesis, signaling, and degradation. © 2014 American Chemical Society.
Source Title:	Analytical Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/116436
ISSN:	15206882
DOI:	10.1021/ac4039652
Appears in Collections:	Staff Publications

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