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|Title:||Lipidomic "deep profiling": An enhanced workflow to reveal new molecular species of signaling lipids|
|Citation:||Narayanaswamy, P., Shinde, S., Sulc, R., Kraut, R., Staples, G., Thiam, C.H., Grimm, R., Sellergren, B., Torta, F., Wenk, M.R. (2014). Lipidomic "deep profiling": An enhanced workflow to reveal new molecular species of signaling lipids. Analytical Chemistry 86 (6) : 3043-3047. ScholarBank@NUS Repository. https://doi.org/10.1021/ac4039652|
|Abstract:||Current mass spectrometry-based lipidomics aims to comprehensively cover wide ranges of lipid classes. We introduce a strategy to capture phospho-monoester lipids and improve the detection of long-chain base phosphates (LCB-Ps, e.g., sphingosine-1-phosphate). Ten novel LCB-Ps (d18:2, t20:1, odd carbon forms) were discovered and characterized in tissues from human and mouse, as well in D. melanogaster and S. cerevisiae. These findings have immediate relevance for our understanding of sphingosine-1-phosphate biosynthesis, signaling, and degradation. © 2014 American Chemical Society.|
|Source Title:||Analytical Chemistry|
|Appears in Collections:||Staff Publications|
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