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Title: Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E e{open}3 and e{open}4 knock-in mice
Authors: Lim, W.L.F.
Lam, S.M.
Shui, G. 
Mondal, A.
Ong, D.
Duan, X.
Creegan, R.
Martins, I.J.
Sharman, M.J.
Taddei, K.
Verdile, G.
Wenk, M.R.
Martins, R.N.
Keywords: APOE KI mice
High cholesterol
High fat
Mass spectrometry
Issue Date: Sep-2013
Citation: Lim, W.L.F., Lam, S.M., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I.J., Sharman, M.J., Taddei, K., Verdile, G., Wenk, M.R., Martins, R.N. (2013-09). Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E e{open}3 and e{open}4 knock-in mice. Neurobiology of Aging 34 (9) : 2217-2224. ScholarBank@NUS Repository.
Abstract: Apolipoprotein E (ApoE) is important in facilitating the transport of lipids (cholesterol, phospholipids, and sulfatides) and plays a fundamental role in normal lipid metabolism. High cholesterol levels increases the risk of developing Alzheimer's disease. In this study, we investigated the effects of a high-fat high cholesterol (HFHC) diet on brain lipid profiles in 95 young and aged APOE e{open}3 and e{open}4 knock-in mice to determine whether diet leads to altered brain levels of a number of glycerophospholipids, sphingolipids, cholesterol precursors, cholesterol, cholesterol oxidation products, and cholesterol esters. The results in this study revealed significant changes in lipid levels. The HFHC-enriched diet influenced the levels of cholesterol esters. A sharp increase in cholesterol ester levels, particularly in the aged APOE e{open}4 diet-enriched group, might be suggestive of abnormal acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT) activity and/or levels. Age exerts appreciable effects on the brain lipidome, especially with regard to polar lipid species. © 2013 Elsevier Inc.
Source Title: Neurobiology of Aging
ISSN: 01974580
DOI: 10.1016/j.neurobiolaging.2013.03.012
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