Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0019731
Title: Comparative plasma lipidome between human and cynomolgus monkey: Are plasma polar lipids good biomarkers for diabetic monkeys?
Authors: Shui, G. 
Stebbins, J.W.
Lam, B.D.
Cheong, W.F.
Lam, S.M.
Gregoire, F.
Kusonoki, J.
Wenk, M.R.
Issue Date: 2011
Citation: Shui, G., Stebbins, J.W., Lam, B.D., Cheong, W.F., Lam, S.M., Gregoire, F., Kusonoki, J., Wenk, M.R. (2011). Comparative plasma lipidome between human and cynomolgus monkey: Are plasma polar lipids good biomarkers for diabetic monkeys?. PLoS ONE 6 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0019731
Abstract: Background: Non-human primates (NHP) are now being considered as models for investigating human metabolic diseases including diabetes. Analyses of cholesterol and triglycerides in plasma derived from NHPs can easily be achieved using methods employed in humans. Information pertaining to other lipid species in monkey plasma, however, is lacking and requires comprehensive experimental analysis. Methodologies/Principal Findings: We examined the plasma lipidome from 16 cynomolgus monkey, Macaca fascicularis, using liquid chromatography coupled with mass spectrometry (LC/MS). We established novel analytical approaches, which are based on a simple gradient elution, to quantify polar lipids in plasma including (i) glycerophospholipids (phosphatidylcholine, PC; phosphatidylethanolamine, PE; phosphatidylinositol, PI; phosphatidylglycerol, PG; phosphatidylserine, PS; phosphatidic acid, PA); (ii) sphingolipids (sphingomyelin, SM; ceramide, Cer; Glucocyl-ceramide, GluCer; ganglioside mannoside 3, GM3). Lipidomic analysis had revealed that the plasma of human and cynomolgus monkey were of similar compositions, with PC, SM, PE, LPC and PI constituting the major polar lipid species present. Human plasma contained significantly higher levels of plasmalogen PE species (p
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/116272
ISSN: 19326203
DOI: 10.1371/journal.pone.0019731
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