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https://doi.org/10.1016/S0092-8674(00)81118-6
Title: | A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors | Authors: | Kamei, Y. Xu, L. Heinzel, T. Torchia, J. Kurokawa, R. Gloss, B. Lin, S.-C. Heyman, R.A. Rose, D.W. Glass, C.K. Rosenfeld, M.G. |
Issue Date: | 3-May-1996 | Citation: | Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R.A., Rose, D.W., Glass, C.K., Rosenfeld, M.G. (1996-05-03). A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85 (3) : 403-414. ScholarBank@NUS Repository. https://doi.org/10.1016/S0092-8674(00)81118-6 | Abstract: | Nuclear receptors regulate gene expression by direct activation of target genes and inhibition of AP-1. Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for limiting amounts of CBP/p300 in cells. Utilizing distinct domains, CBP directly interacts with the ligand-binding domain of multiple nuclear receptors and with the p160 nuclear receptor coactivators, which upon cloning have proven to be variants of the SRC-1 protein. Because CBP represents a common factor, required in addition to distinct coactivators for function of nuclear receptors, CREB, and AP-1, we suggest that CBP/p300 serves as an integrator of multiple signal transduction pathways within the nucleus. | Source Title: | Cell | URI: | http://scholarbank.nus.edu.sg/handle/10635/116187 | ISSN: | 00928674 | DOI: | 10.1016/S0092-8674(00)81118-6 |
Appears in Collections: | Staff Publications |
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