Please use this identifier to cite or link to this item: https://doi.org/10.1159/000346231
Title: Efficacy and safety of MLC601 (NeuroAiD®), a traditional chinese medicine, in poststroke recovery: A systematic review
Authors: Siddiqui, F.J.
Venketasubramanian, N.
Chan, E.S.-Y. 
Chen, C.
Keywords: Barthel Index
Danqi Piantang Jiaonang
Functional independence
Meta-analysis
MLC601
NeuroAiD
Randomized
Recovery
Stroke
Systematic review
Trial
Issue Date: Mar-2013
Source: Siddiqui, F.J., Venketasubramanian, N., Chan, E.S.-Y., Chen, C. (2013-03). Efficacy and safety of MLC601 (NeuroAiD®), a traditional chinese medicine, in poststroke recovery: A systematic review. Cerebrovascular Diseases 35 (SUPPL.1) : 8-17. ScholarBank@NUS Repository. https://doi.org/10.1159/000346231
Abstract: Background: Subsequent to a pooled analysis of 2 trials, several more studies have been published assessing the benefit of MLC601 in stroke patients. Hence, it is timely to conduct an updated meta-analysis to frame the interpretation of the results of an ongoing large multicenter, randomized, double-blind, placebo-controlled study. Therefore, we conducted a systematic review of the efficacy of MLC601 in improving the recovery of stroke patients. Methods: PubMed® and the Cochrane Library® databases were searched for trials evaluating MLC601 in stroke patients. Primary outcome was functional independence, assessed by the Barthel Index or the Diagnostic Therapeutic Effects of Apoplexy scoring system, item 8. Secondary outcomes were improvement in functional independence scores, motor recovery, reduction in visual field defect and increase in cerebral blood flow. Two authors performed the article selection, appraisal and data extraction while resolving differences through discussion or consulting a third author. Data were analyzed in RevMan5®. Meta-analysis was conducted using a random effects model. Results: This review included 6 studies with overall low risk of bias but some clinical heterogeneity. MLC601 increased the chances of achieving functional independence after stroke compared to control treatments (risk ratio, 2.35; 95% CI, 1.31-4.23). No deaths and 4 serious adverse events were reported in the MLC601 group, although detail was sparse with inconsistent reporting. Conclusions: There is evidence that MLC601 as an add-on to standard treatment could be effective in improving functional independence and motor recovery and is safe for patients with primarily nonacute stable stroke. Copyright © 2013 S. Karger AG, Basel.
Source Title: Cerebrovascular Diseases
URI: http://scholarbank.nus.edu.sg/handle/10635/116168
ISSN: 10159770
DOI: 10.1159/000346231
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