Please use this identifier to cite or link to this item: https://doi.org/10.1126/science.1188280
Title: Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
Authors: Ouchi, N.
Higuchi, A.
Ohashi, K.
Oshima, Y.
Gokce, N.
Shibata, R.
Akasaki, Y.
Shimono, A. 
Walsh, K.
Issue Date: 23-Jul-2010
Citation: Ouchi, N., Higuchi, A., Ohashi, K., Oshima, Y., Gokce, N., Shibata, R., Akasaki, Y., Shimono, A., Walsh, K. (2010-07-23). Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 329 (5990) : 454-457. ScholarBank@NUS Repository. https://doi.org/10.1126/science.1188280
Abstract: Adipose tissue secretes proteins referred to as adipokines, many of which promote inflammation and disrupt glucose homeostasis. Here we show that secreted frizzled-related protein 5 (Sfrp5), a protein previously linked to the Wnt signaling pathway, is an anti-inflammatory adipokine whose expression is perturbed inmodels of obesity and type 2 diabetes. Sfrp5-deficient mice fed a high-calorie diet developed severe glucose intolerance and hepatic steatosis, and their adipose tissue showed an accumulation of activated macrophages that was associated with activation of the c-Jun N-terminal kinase signaling pathway. Adenovirus-mediated delivery of Sfrp5 to mouse models of obesity ameliorated glucose intolerance and hepatic steatosis. Thus, in the setting of obesity, Sfrp5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue.
Source Title: Science
URI: http://scholarbank.nus.edu.sg/handle/10635/115929
ISSN: 00368075
DOI: 10.1126/science.1188280
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