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|Title:||Positioning and maintenance of embryonic body wall muscle attachments in C. elegans requires the mup-1 gene|
|Authors:||Goh, P.-Y. |
Muscle attachment pattern
|Source:||Goh, P.-Y.,Bogaert, T. (1991-03). Positioning and maintenance of embryonic body wall muscle attachments in C. elegans requires the mup-1 gene. Development 111 (3) : 667-681. ScholarBank@NUS Repository.|
|Abstract:||As part of a general study of genes specifying a pattern of muscle attachments, we identified and genetically characterised mutants in the mup-1 gene. The body wall muscles of early stage mup-1 embryos have a wild-type myofilament pattern but may extend ectopic processes. Later in embryogenesis, some body wall muscles detach from the hypodermis. Genetic analysis suggests that mup-1 has both a maternal and a zygotic component and is not required for postembryonic muscle growth and attachment. mup-1 mutants are suppressed by mutations in several genes that encode extracellular matrix components. We propose that mup-1 may encode a cell surface/extracellular matrix molecule required both for the positioning of body wall muscle attachments in early embryogenesis and the subsequent maintenance of these attachments to the hypodermis until after cuticle synthesis.|
|Appears in Collections:||Staff Publications|
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