Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/113359
Title: Angiotensin AT1 receptor subtypes in the rabbit pulmonary artery
Authors: Sim, M.K.
Lim, S.L. 
Issue Date: 1998
Citation: Sim, M.K.,Lim, S.L. (1998). Angiotensin AT1 receptor subtypes in the rabbit pulmonary artery. Receptors and Channels 5 (6) : 323-329. ScholarBank@NUS Repository.
Abstract: The present ligand binding study showed that the rabbit pulmonary artery contained two subtypes of losartan-sensitive angiotensin receptor. The two receptor subtypes are differentially distributed. The high affinity receptor subtype is located predominantly in the cardia end of the artery while the low affinity receptor subtype is found mainly in the pulmonary portion of the artery. The K(d) for the high and low affinity receptors for sar1,Ile8-angiotensin II was found to be 0.25 ± 0.005 and 0.88 ± 0.02 nM, respectively; and for angiotensin II to be 0.43 ± 0.001 and 0.96 ± 0.02 nM, respectively. In the presence of 1 mM GppNHp, the high affinity receptor subtype was converted to the low affinity subtype, indicating that it is G-protein coupled. 1 mM GppNHp had no effect on the low affinity receptor subtype, The present data support the findings of an earlier functional study which also showed the existence and similar differential distribution of two losartan-sensitive angiotensin receptors in the rabbit pulmonary artery. However, the significance of these findings in regard to the regulation of pulmonary circulation in normal and pathological conditions remains to be investigated.
Source Title: Receptors and Channels
URI: http://scholarbank.nus.edu.sg/handle/10635/113359
ISSN: 10606823
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

29
checked on Nov 2, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.