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Title: | Role of the Nucleus Incertus in Cognition | Authors: | WU YOU | Keywords: | Nucleus Incertus, stress, cognition, prefrontal cortex, chemoarchitecture, HP-mPFC LTP, behavior | Issue Date: | 14-Jul-2014 | Citation: | WU YOU (2014-07-14). Role of the Nucleus Incertus in Cognition. ScholarBank@NUS Repository. | Abstract: | Stress is an important modulator of cognition. Recent evidence suggests that the nucleus incertus (NI) plays a potential role in stress and cognition modulation. In this thesis, to test the hypothesis that the NI plays a critical role in cognition under stress, especially in PFC modulation: (1) The chemoarchitecture of NI neurons projecting to mPFC and ACC was characterized, demonstrating the high expression levels of CRF1 receptor, RLN3 and dopamine D2S in NI-PFC projection neurons; (2) The role of the NI in stressor-induced HP-mPFC LTP modulation was validated by the rescue effects of intra-NI CRF1 antagonist treatment on HP-mPFC LTP suppression caused by elevation stress; (3) The role of the NI in stress-induced mPFC working memory behavior modulation was also studied by delayed spatial win-shift task. All results strongly suggested the critical role of NI in PFC modulation under stress. | URI: | http://scholarbank.nus.edu.sg/handle/10635/113314 |
Appears in Collections: | Master's Theses (Open) |
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