Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/113282
Title: | Metabonomic Study of Amyotrophic Lateral Sclerosis in SOD1G93A Mouse Model | Authors: | AW CHIU CHEONG | Keywords: | ALS, MND, Metabolomic, Metabonomic, SOD1G93A, GC-TOFMS | Issue Date: | 8-Aug-2014 | Citation: | AW CHIU CHEONG (2014-08-08). Metabonomic Study of Amyotrophic Lateral Sclerosis in SOD1G93A Mouse Model. ScholarBank@NUS Repository. | Abstract: | Amyotrophic Lateral Sclerosis (ALS), the most common of the Motor Neuron Diseases (MND), is characterized by the progressive degeneration of the upper and lower motor neurons. Death ensues in 3-5 years from diagnosis which consists of scoring and a physical examination to rule out other motor disorders. Riluzole is the only drug approved so far and it offers only a modest 2-3 months of extension of life with little symptomatic relief. The search for an effective therapy is a daunting uphill task with numerous agents failing in clinical trials despite showing efficacy in the preclinical disease endpoints. Here we present a panel of metabolites covering some of the hallmark pathways of the disease, ranging from energy metabolism, to mitochondria health. Sharing common pathways and specific metabolites with a clinical metabonomic study, our study offers opportunity for the development of translatable approaches to measuring drug efficacy preclinically. | URI: | http://scholarbank.nus.edu.sg/handle/10635/113282 |
Appears in Collections: | Master's Theses (Open) |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
AwCC.pdf | 853.87 kB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.