Please use this identifier to cite or link to this item: https://doi.org/10.1038/26020
Title: Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling
Authors: Sampath, K. 
Rubinstein, A.L.
Cheng, A.M.S.
Liang, J.O.
Fekany, K.
Solnica-Krezel, L.
Korzh, V. 
Halpern, M.E.
Wright, C.V.E.
Issue Date: 10-Sep-1998
Citation: Sampath, K.,Rubinstein, A.L.,Cheng, A.M.S.,Liang, J.O.,Fekany, K.,Solnica-Krezel, L.,Korzh, V.,Halpern, M.E.,Wright, C.V.E. (1998-09-10). Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature 395 (6698) : 185-189. ScholarBank@NUS Repository. https://doi.org/10.1038/26020
Abstract: Zebrafish cyclops (cyc) mutations cause deficiencies in the dorsal mesendoderm and ventral neural tube, leading to neural defects and cyclopia. Here we report that cyc encodes a transforming growth factor-β (TGF-β)- related intercellular signalling molecule that is similar to mouse nodal. cyc is expressed in dorsal mesendoderm at gastrulation and in the prechordal plate until early somitogenesis. Expression reappears transiently in the left lateral-plate mesoderm, and in an unprecedented asymmetric pattern in the left forebrain. Injection of cyc RNA non-autonomously restores sonic hedgehog-expressing cells of the ventral brain and floorplate that are absent in cyc mutants, whereas inducing activities are abolished by cycm294, a mutation of a conserved cysteine in the mature ligand. Our results indicate that cyc provides an essential non-cell-autonomous signal at gastrulation, leading to induction of the floorplate and ventral brain.
Source Title: Nature
URI: http://scholarbank.nus.edu.sg/handle/10635/112932
ISSN: 00280836
DOI: 10.1038/26020
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

384
checked on Nov 15, 2018

Page view(s)

38
checked on Nov 16, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.