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Title: Small is beautiful: Comparative genomics with the pufferfish (Fugu rubripes)
Authors: Elgar, G.
Sandford, R.
Aparicio, S.
Macrae, A.
Venkatesh, B. 
Brenner, S.
Issue Date: Apr-1996
Citation: Elgar, G., Sandford, R., Aparicio, S., Macrae, A., Venkatesh, B., Brenner, S. (1996-04). Small is beautiful: Comparative genomics with the pufferfish (Fugu rubripes). Trends in Genetics 12 (4) : 145-150. ScholarBank@NUS Repository.
Abstract: As the Human Genome Project advances, it is clear that the emphasis will switch from accumulation of data to their interpretation. Comparative genomics provides a powerful way in which to analyse sequence data. Indeed, there is already a long list of 'model' organisms, which allow comparative analyses in a variety of ways. The very small vertebrate genome of the pufferfish provides a simple and economical way of comparing sequence data from mammals and fish, representing a large evolutionary divergence and so permitting the identification of essential elements that are still present in both species. These elements include genes and the associated machinery that controls their expression; elements that, in many cases, have survived the test of time.
Source Title: Trends in Genetics
ISSN: 01689525
DOI: 10.1016/0168-9525(96)10018-4
Appears in Collections:Staff Publications

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