Please use this identifier to cite or link to this item: https://doi.org/10.1158/0008-5472.CAN-07-5291
Title: Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells
Authors: Jurvansuu, J.
Zhao, Y.
Leung, D.S.Y.
Boulaire, J.
Yuan, H.Y.
Ahmed, S. 
Wang, S. 
Issue Date: 15-Jun-2008
Citation: Jurvansuu, J., Zhao, Y., Leung, D.S.Y., Boulaire, J., Yuan, H.Y., Ahmed, S., Wang, S. (2008-06-15). Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells. Cancer Research 68 (12) : 4614-4622. ScholarBank@NUS Repository. https://doi.org/10.1158/0008-5472.CAN-07-5291
Abstract: The failure of current glioma therapies is mainly due to the ability of the tumor cells to invade extensively the surrounding healthy brain tissue, hence escaping localized treatments. Neural stem cells (NSC) are able to home in on tumor foci at sites distant from the main tumor mass, possibly enabling treatment of scattered glioma clusters. To make the strategy more effective, we performed a cDNA expression library screening to identify the candidate genes that once overexpressed would enhance the tropism of NSCs for gliomas. Here, we show that a previously unannotated gene, the one encoding transmembrane protein 18 (TMEM18), is one such gene. Overexpression of TMEM18 was seen in the current study to provide NSCs and neural precursors an increased migration capacity toward glioblastoma cells in vitro and in the rat brain. Functional inactivation of the TMEM18 gene resulted in almost complete loss of the migration activity of these cells. Thus, TMEM18 is a novel cell migration modulator. Overexpression of this protein could be favorably used in NSC-based glioma therapy. ©2008 American Association for Cancer Research.
Source Title: Cancer Research
URI: http://scholarbank.nus.edu.sg/handle/10635/112145
ISSN: 00085472
DOI: 10.1158/0008-5472.CAN-07-5291
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

51
checked on Oct 11, 2018

WEB OF SCIENCETM
Citations

53
checked on Sep 25, 2018

Page view(s)

23
checked on Sep 21, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.