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|Title:||Solid-phase synthesis of peptidomimetic oligomers with a phosphodiesterase backbone|
|Source:||Lin, P., Ganesan, A. (1998-03-03). Solid-phase synthesis of peptidomimetic oligomers with a phosphodiesterase backbone. Bioorganic and Medicinal Chemistry Letters 8 (5) : 511-514. ScholarBank@NUS Repository. https://doi.org/10.1016/S0960-894X(98)00064-X|
|Abstract:||An unnatural biopolymer is described in which amino acid side-chains are presented along a negatively charged phosphodiester backbone. For this purpose, a series of phosphoramidite monomers was prepared from chiral 1,2-diols. These were efficiently converted into oligomers using standard coupling conditions on an automated DNA synthesizer.|
|Source Title:||Bioorganic and Medicinal Chemistry Letters|
|Appears in Collections:||Staff Publications|
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