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https://scholarbank.nus.edu.sg/handle/10635/112045
| Title: | Regulation of HLA class I gene expression in human colorectal carcinoma | Authors: | Soong, T.W. Oei, A.A. Hui, K.M. |
Keywords: | Colorectal cancer HLA class I Locus-specific suppression Non-coordinated Trans-acting elements |
Issue Date: | Feb-1991 | Citation: | Soong, T.W., Oei, A.A., Hui, K.M. (1991-02). Regulation of HLA class I gene expression in human colorectal carcinoma. Seminars in Cancer Biology 2 (1) : 23-33. ScholarBank@NUS Repository. | Abstract: | The under-representation of HLA antigens in human tumors is usually associated with a poor prognosis. In this report, the expression of HLA class I genes in human colorectal carcinomas was studied using HLA-A and HLA-B locus-specific probes. Over 50% of the colorectal carcinomas studied showed a reduction in the amount of steady state HLA class I mRNA. For some carcinomas, non-coordinated regulation of the HLA-A and HLA-B genes was observed. The mechanism of HLA suppression was investigated and is most likely due to the presence of transcriptional regulatory elements. © 1991 by W.B. Saunders Company. | Source Title: | Seminars in Cancer Biology | URI: | http://scholarbank.nus.edu.sg/handle/10635/112045 | ISSN: | 1044579X |
| Appears in Collections: | Staff Publications |
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