Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0378-1119(97)00385-5
Title: Partial nucleotide sequence and organisation of extrachromosomal plastid-like DNA in Plasmodium berghei
Authors: Yap, M.W.C.
Kara, U.A.K.
Ten Heggeler-Bordier, B.
Ting, R.C.Y. 
Tan, T.M.C. 
Keywords: Extrachromosomal DNA
Malaria
Plasmodium berghei
Plastid
Issue Date: 24-Oct-1997
Citation: Yap, M.W.C., Kara, U.A.K., Ten Heggeler-Bordier, B., Ting, R.C.Y., Tan, T.M.C. (1997-10-24). Partial nucleotide sequence and organisation of extrachromosomal plastid-like DNA in Plasmodium berghei. Gene 200 (1-2) : 91-98. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-1119(97)00385-5
Abstract: The murine malaria parasite Plasmodium berghei contains a plastid-like extrachromosomal genome. This genome is 30.7 kb in size and is transcriptionally active as shown by RT-PCR. DNA sequence analysis of the genome reveals 69.9-95.5% homology to sequences of the 35-kb extrachromosomal circle found in the human malaria species Plasmodium falciparum. Homologous sequences include regions of genes for the ssu-rRNA, lsu-rRNA, rpo B and clusters of t-RNAs. Sequence variation between the two Plasmodium species exists in the non-coding interspacing regions. A physical map has been constructed for the P. berghei circle, indicating the EcoRI and HindIII restriction sites as well as the arrangement of the rRNA, rpo B and tRNA genes. Arrangement of these genes is similar to that found on the P. falciparum 35-kb circle. The P. berghei circular element is distinct from the mitochondrial 6-kb DNA of both the murine and the human Plasmodium species. Preliminary results indicate that the circle may be a useful target for drug therapy.
Source Title: Gene
URI: http://scholarbank.nus.edu.sg/handle/10635/112010
ISSN: 03781119
DOI: 10.1016/S0378-1119(97)00385-5
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Sep 19, 2018

WEB OF SCIENCETM
Citations

11
checked on Sep 19, 2018

Page view(s)

30
checked on Mar 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.