Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/111940
Title: Induction of tumour-specific immunity by manipulating the expression of major histocompatibility complex molecules on tumour cells
Authors: Hui, K.M. 
Keywords: DNA-mediated gene transfer
Major histocompatibility complex
Tumour-specific immunity
Issue Date: Nov-1990
Citation: Hui, K.M. (1990-11). Induction of tumour-specific immunity by manipulating the expression of major histocompatibility complex molecules on tumour cells. FEMS Microbiology Letters 64 (4) : 215-221. ScholarBank@NUS Repository.
Abstract: Class I major histocompatibility complex (MHC) molecules form part of the target structure recognized by the host cytotoxic T cells (CTL) to reject tumour cells. Many types of malignant tumour cells are reported in which expression of class I MHC genes is down-regulated. By DNA-mediated gene transfer, it is possible to re-express the 'missing' syngeneic (genetically identical) or to introduce 'new' allogeneic (genetically dissimilar) class I MHC genes into these MHC-deficient tumours. In both instances, the immunogenicity of the transfected tumour cells is greatly enhanced and results in their rejection in vivo. More importantly, these 'modified' tumour cells, which are positive for class I MHC molecules, can simultaneously generate an immunity against the 'wildtype' tumour cells which do not express these molecules. These observations suggest the distinct possibility of using gene transfer as a molecular immunotherapeutic approach to abrogate tumour growth. © 1990.
Source Title: FEMS Microbiology Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/111940
ISSN: 03781097
Appears in Collections:Staff Publications

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