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https://scholarbank.nus.edu.sg/handle/10635/111790
| Title: | Assembly of the TAN-1057 A/B heterocycle from a dehydroalanine precursor | Authors: | Lin, P. Ganesan, A. |
Keywords: | Amino acids Antibiotics Cyclizations Nucleophilic additions Tandem reactions |
Issue Date: | 2000 | Citation: | Lin, P.,Ganesan, A. (2000). Assembly of the TAN-1057 A/B heterocycle from a dehydroalanine precursor. Synthesis (14) : 2127-2130. ScholarBank@NUS Repository. | Abstract: | A tandem reaction process was used to form the tetrahydropyrimidinone core of the TAN-1057 A and B dipeptide antibiotics. Michael addition of ammonia to a dehydroalanine derivative, followed by intramolecular displacement of an S-methylisothiourea assembles the tetrahydropyrimidinone in one-step. | Source Title: | Synthesis | URI: | http://scholarbank.nus.edu.sg/handle/10635/111790 | ISSN: | 00397881 |
| Appears in Collections: | Staff Publications |
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