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Title: Assembly of the TAN-1057 A/B heterocycle from a dehydroalanine precursor
Authors: Lin, P.
Ganesan, A. 
Keywords: Amino acids
Nucleophilic additions
Tandem reactions
Issue Date: 2000
Source: Lin, P.,Ganesan, A. (2000). Assembly of the TAN-1057 A/B heterocycle from a dehydroalanine precursor. Synthesis (14) : 2127-2130. ScholarBank@NUS Repository.
Abstract: A tandem reaction process was used to form the tetrahydropyrimidinone core of the TAN-1057 A and B dipeptide antibiotics. Michael addition of ammonia to a dehydroalanine derivative, followed by intramolecular displacement of an S-methylisothiourea assembles the tetrahydropyrimidinone in one-step.
Source Title: Synthesis
ISSN: 00397881
Appears in Collections:Staff Publications

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