α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength

Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M112.403774

Title:	α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength
Authors:	Thomas, W.A. Boscher, C. Chu, Y.-S. Cuvelier, D. Martinez-Rico, C. Seddiki, R. Heysch, J. Ladoux, B. Thiery, J.P. Mege, R.-M. Dufour, S.
Issue Date:	15-Feb-2013
Citation:	Thomas, W.A., Boscher, C., Chu, Y.-S., Cuvelier, D., Martinez-Rico, C., Seddiki, R., Heysch, J., Ladoux, B., Thiery, J.P., Mege, R.-M., Dufour, S. (2013-02-15). α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength. Journal of Biological Chemistry 288 (7) : 4957-4969. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M112.403774
Abstract:	Background: Cadherin interactions with catenins are crucial for intercellular adhesion. Results: αE-catenin and vinculin cooperate to promote the time-dependent reinforcement of cadherin-mediated adhesions. Conclusion: aE-catenin and vinculin form a mechanoresponsive link between cadherin and the underlying actin cytoskeleton. Significance: The force-dependent modulation of a-catenin and vinculin recruitment contributes to the development of cadherin adhesion strength.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title:	Journal of Biological Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/110800
ISSN:	00219258
DOI:	10.1074/jbc.M112.403774
Appears in Collections:	Staff Publications

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