Please use this identifier to cite or link to this item: https://doi.org/10.3349/ymj.2009.50.4.464
Title: Divide and conquer: Progress in the molecular stratification of cancer
Authors: Tan, P. 
Keywords: Cancer genomics
Molecular stratification
Targeted therapies
Issue Date: Aug-2009
Citation: Tan, P. (2009-08). Divide and conquer: Progress in the molecular stratification of cancer. Yonsei Medical Journal 50 (4) : 464-473. ScholarBank@NUS Repository. https://doi.org/10.3349/ymj.2009.50.4.464
Abstract: Cancer remains an outstanding cause of global morbidity and mortality, despite intensive research and unprecedented insights into the basic mechanisms of cancer development. A plethora of clinical and experimental evidence suggests that cancers from individual patients are likely to be molecularly heterogeneous in their use of distinct oncogenic pathways and biological programs. Efforts to significantly impact cancer patient outcomes will almost certainly require the development of robust strategies to subdivide such heterogeneous panels of cancers into biologically and clinically homogenous subgroups, for the purposes of personalizing treatment protocols and identifying optimal drug targets. In this review, I describe recent progress in the development of both targeted and genome-wide approaches for the molecular stratification of cancers, drawing examples from both the haematopoietic and solid tumor malignancies. © Copyright: Yonsei University College of Medicine 2009.
Source Title: Yonsei Medical Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/110700
ISSN: 05135796
DOI: 10.3349/ymj.2009.50.4.464
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

2
checked on May 19, 2018

WEB OF SCIENCETM
Citations

2
checked on Apr 3, 2018

Page view(s)

44
checked on Mar 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.