Please use this identifier to cite or link to this item:
|Title:||Assessing applicability when comparing medical interventions: AHRQ and the Effective Health Care Program|
Heterogeneity of treatment effect
|Citation:||Atkins, D., Chang, S.M., Gartlehner, G., Buckley, D.I., Whitlock, E.P., Berliner, E., Matchar, D. (2011-11). Assessing applicability when comparing medical interventions: AHRQ and the Effective Health Care Program. Journal of Clinical Epidemiology 64 (11) : 1198-1207. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jclinepi.2010.11.021|
|Abstract:||Objective: To describe a systematic approach for identifying, reporting, and synthesizing information to allow consistent and transparent consideration of the applicability of the evidence in a systematic review according to the Population, Intervention, Comparator, Outcome, Setting domains. Study Design and Setting: Comparative effectiveness reviews need to consider whether available evidence is applicable to specific clinical or policy questions to be useful to decision makers. Authors reviewed the literature and developed guidance for the Effective Health Care program. Results: Because applicability depends on the specific questions and needs of the users, it is difficult to devise a valid uniform scale for rating the overall applicability of individual studies or body of evidence. We recommend consulting stakeholders to identify the factors most relevant to applicability for their decisions. Applicability should be considered separately for benefits and harms. Observational studies can help determine whether trial populations and interventions are representative of "real world" practice. Reviewers should describe differences between available evidence and the ideally applicable evidence for the question being asked and offer a qualitative judgment about the importance and potential effect of those differences. Conclusion: Careful consideration of applicability may improve the usefulness of systematic reviews in informing practice and policy. © 2011 Elsevier Inc. All rights reserved.|
|Source Title:||Journal of Clinical Epidemiology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 21, 2019
WEB OF SCIENCETM
checked on Feb 13, 2019
checked on Jan 18, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.