Please use this identifier to cite or link to this item: https://doi.org/10.1002/hup.1068
Title: Opioid use affects antioxidant activity and purine metabolism: Preliminary results
Authors: Mannelli, P.
Patkar, A.
Rozen, S. 
Matson, W.
Krishnan, R. 
Kaddurah-Daouk, R.
Keywords: Addiction
Metabolic profiling
Metabolomics
Metabonomics
Methadone
Opioid detoxification
Issue Date: 2009
Citation: Mannelli, P., Patkar, A., Rozen, S., Matson, W., Krishnan, R., Kaddurah-Daouk, R. (2009). Opioid use affects antioxidant activity and purine metabolism: Preliminary results. Human Psychopharmacology 24 (8) : 666-675. ScholarBank@NUS Repository. https://doi.org/10.1002/hup.1068
Abstract: Objective: More must be learned about metabolic and biochemical alterations that contribute to the development and expression of drug dependence. Experimental opioid administration influences mechanisms and indices of oxidative stress, such as antioxidant compounds and purine metabolism. We examined perturbations of neurotransmitter-related pathways in opioid dependence (OD). Methods: In this preliminary study, we used a targeted metabolomics platform to explore whether biochemical changes were associated with OD by comparing OD individuals (n = 14) and non-drug users (n = 10). Results: OD patients undergoing short-term methadone detoxification showed altered oxidation-reduction activity, as confirmed by higher plasma levels of α- and γ- tocopherol and increased GSH/GSSG ratio. OD individuals had also altered purine metabolism, showing increased concentration of guanine and xanthosine, with decreased guanosine, hypoxanthine and hypoxanthine/xanthine and xanthine/xanthosine ratios. Other drug use in addition to opioids was associated with partly different biochemical changes. Conclusions: This is a preliminary investigation using metabolomics and showing multiple peripheral alterations of metabolic pathways in OD. Further studies should explore the metabolic profile of conditions of opioid abuse, withdrawal and long-term abstinence in relation to agonist and antagonist treatment and investigate biochemical signatures of opioid substances and medications. Copyright © 2009 John Wiley & Sons, Ltd.
Source Title: Human Psychopharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/110602
ISSN: 08856222
DOI: 10.1002/hup.1068
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

30
checked on Aug 18, 2018

WEB OF SCIENCETM
Citations

28
checked on Jul 16, 2018

Page view(s)

40
checked on Jun 8, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.