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Title: Effects of heart disease on depression treatment: Results from the COMED study
Authors: Kerber, K.B.
Wisniewski, S.R.
Luther, J.F.
Leuchter, A.F.
D'Empaire, I.
Trivedi, M.H.
Rush, A.J. 
Keywords: CO-MED study
Depression treatment
Heart disease
Issue Date: Jan-2012
Citation: Kerber, K.B., Wisniewski, S.R., Luther, J.F., Leuchter, A.F., D'Empaire, I., Trivedi, M.H., Rush, A.J. (2012-01). Effects of heart disease on depression treatment: Results from the COMED study. General Hospital Psychiatry 34 (1) : 24-34. ScholarBank@NUS Repository.
Abstract: Objective: To determine the impact of self-reported heart disease (HD) on major depressive disorder (MDD) treatment outcomes. Method: This single-blind, 7-month prospective randomized trial enrolled 665 participants, 18-75 years old, from six primary and nine psychiatric care sites across the USA. Participants had at least moderately severe (baseline 17-item Hamilton Rating Scale of Depression ≥16), nonpsychotic chronic and/or recurrent MDD. Participants with and without self-reported HD were randomized into three treatment groups (1:1:1 ratio): escitalopram plus placebo, bupropion sustained-release plus escitalopram or venlafaxine extended-release plus mirtazapine. The primary outcome (remission) was defined by the last two consecutive 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR 16) ratings: one had to be
Source Title: General Hospital Psychiatry
ISSN: 01638343
DOI: 10.1016/j.genhosppsych.2011.08.018
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