Please use this identifier to cite or link to this item: https://doi.org/10.1038/npp.2013.271
Title: Association of depressive symptoms with hippocampal volume in 1936 adults
Authors: Brown, E.S.
Hughes, C.W.
McColl, R.
Peshock, R.
King, K.S.
Rush, A.J. 
Keywords: hippocampus
mood
neurodegeneration
quick inventory of depressive symptomatology
total brain volume
Issue Date: Feb-2014
Citation: Brown, E.S., Hughes, C.W., McColl, R., Peshock, R., King, K.S., Rush, A.J. (2014-02). Association of depressive symptoms with hippocampal volume in 1936 adults. Neuropsychopharmacology 39 (3) : 770-779. ScholarBank@NUS Repository. https://doi.org/10.1038/npp.2013.271
Abstract: Hippocampal atrophy is reported in major depressive disorder (MDD). However, sample sizes were generally modest, and participant characteristics, including age, differed between studies. This study used a community sample to examine relationships between current depressive symptom severity and hippocampal volume across the adult lifespan. A total of 1936 adults with magnetic resonance images of the brain and Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) scores were included. Brain volumes were quantified using the FSL program. Multiple linear regressions were performed using left, right, and total hippocampal volume as criterion variables, and predictor variables of QIDS-SR total, total brain volume, age, gender, education, psychotropic medications, alcohol use, and race/ethnicity. Post hoc analyses were conducted in participants with QIDS-SR scores ≥11 (moderate or greater depressive symptom severity) and
Source Title: Neuropsychopharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/110492
ISSN: 0893133X
DOI: 10.1038/npp.2013.271
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