Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1751-7893.2011.00304.x
Title: The Singapore flagship programme in translational and clinical research in psychosis
Authors: Chong, S.-A.
Campbell, A.
Chee, M. 
Liu, J.
Marx, C.
Mcgorry, P.
Subramaniam, M.
Yung, A.
Keefe, R.S.
Keywords: Genetics
Neurocognition
Pregnenolone
Schizophrenia
Ultra-high risk
Issue Date: Nov-2011
Citation: Chong, S.-A., Campbell, A., Chee, M., Liu, J., Marx, C., Mcgorry, P., Subramaniam, M., Yung, A., Keefe, R.S. (2011-11). The Singapore flagship programme in translational and clinical research in psychosis. Early Intervention in Psychiatry 5 (4) : 290-300. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1751-7893.2011.00304.x
Abstract: Aim: This paper describes the rationale, aims and development of the Singapore Translational and Clinical Research in Psychosis, which is a 5-year programme. Methods: The authors provide a selective review of the pertinent findings from the clinical, neuropsychological, genetics and neuroimaging studies on high-risk population and how they were factored in the hypotheses and design of this translational clinical research programme. Results: This programme, which draws upon the previous work of various groups and the experience of the investigators of this consortium, comprises three interlinked studies. The first is a genome-wide association and copy number variation analysis using the diagnostic phenotype of schizophrenia and cognitive phenotypes, and a joint genome-wide analysis performed by combining our data with other datasets to increase the power to detect genetic risk factors. The second is a prospective study of a large group of individuals who are assessed to be at ultra-high risk of psychosis, and the third is a randomized controlled trial to improve neurocognition in patients with schizophrenia. Conclusion: The convergence of various factors including the unique structured characteristics of the Singaporean society, the presence of political will with availability of funding and the established research infrastructure make it possible to accrue the sample size for adequate power to elucidate biomarkers of disease risk and resilience. © 2011 Blackwell Publishing Asia Pty Ltd.
Source Title: Early Intervention in Psychiatry
URI: http://scholarbank.nus.edu.sg/handle/10635/110456
ISSN: 17517885
DOI: 10.1111/j.1751-7893.2011.00304.x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

6
checked on Jul 11, 2018

WEB OF SCIENCETM
Citations

6
checked on Jul 11, 2018

Page view(s)

38
checked on Jun 8, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.