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Title: Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: A meta-analysis of clinical evidence
Authors: Ho, F.C.H.
Tham, I.W.K.
Earnest, A. 
Lee, K.M.
Lu, J.J.
Keywords: Lymph nodes
Lymphatic metastasis
Nasopharyngeal cancer
Issue Date: 21-Mar-2012
Citation: Ho, F.C.H., Tham, I.W.K., Earnest, A., Lee, K.M., Lu, J.J. (2012-03-21). Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: A meta-analysis of clinical evidence. BMC Cancer 12 : -. ScholarBank@NUS Repository.
Abstract: Background: The characteristics of cervical lymphatic metastasis in nasopharyngeal carcinoma (NPC) are not completely understood. As such, radiotherapy to the entire lymphatic of the neck bilaterally has been empirically practiced even in early stage disease, although not supported by clinical evidence. We studied the pattern and probability of nodal metastasis through a meta-analysis of published evidences, with an aim to establish an evidence-based guideline for selecting and delineation of clinical target volume of neck lymphatics for conformation radiation for NPC.Methods: A literature search yielded an initial 411 original articles, and 13 studies with 2920 NPC cases staged via MRI were included in this analysis. The occurrence of nodal metastasis was calculated and analyzed according to the respective regional nodal levels.Results: 85% of NPC cases presented with lymphadenopathy. The most commonly involved regions include retropharyngeal (69%) and level II lymph nodes (70%). The overall probability of levels III, IV, and V nodal involvement are 45%, 11%, and 27%, respectively. Low-risk node groups included the supraclavicular, levels IA/IB and VI nodes, and parotid nodes with involvement rates at 3%, 0%, 3%, 0%, and 1%, respectively. Nodal metastases followed an orderly pattern and the probability of "skip" metastasis between levels varied between 0.5-7.9%.Conclusions: Lymph node metastasis in NPC follows a predictable and orderly pattern. The rarity of metastasis in certain nodal groups and "skip" metastasis suggest that reduced treatment volume is feasible in conformal radiotherapy for NPC. © 2012 Ho et al; licensee BioMed Central Ltd.
Source Title: BMC Cancer
ISSN: 14712407
DOI: 10.1186/1471-2407-12-98
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