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Title: In vivo biocompatibility of two PEG/PAA interpenetrating polymer networks as corneal inlays following deep stromal pocket implantation
Authors: Tan, X.W.
Hartman, L.
Tan, K.P.
Poh, R.
Myung, D.
Zheng, L.L.
Waters, D.
Noolandi, J.
Beuerman, R.W.
Frank, C.W.
Ta, C.N.
Tan, D.T.H.
Mehta, J.S. 
Issue Date: Apr-2013
Citation: Tan, X.W., Hartman, L., Tan, K.P., Poh, R., Myung, D., Zheng, L.L., Waters, D., Noolandi, J., Beuerman, R.W., Frank, C.W., Ta, C.N., Tan, D.T.H., Mehta, J.S. (2013-04). In vivo biocompatibility of two PEG/PAA interpenetrating polymer networks as corneal inlays following deep stromal pocket implantation. Journal of Materials Science: Materials in Medicine 24 (4) : 967-977. ScholarBank@NUS Repository.
Abstract: This study compared the effects of implanting two interpenetrating polymer networks (IPNs) into rabbit corneas. The first (Implant 1) was based on PEG-diacrylate, the second (Implant 2) was based on PEG-diacrylamide. There were inserted into deep stromal pockets created using a manual surgical technique for either 3 or 6 months. The implanted corneas were compared with normal and sham-operated corneas through slit lamp observation, anterior segment optical coherence tomography, in vivo confocal scanning and histological examination. Corneas with Implant 1 (based on PEG-diacrylate) developed diffuse haze, ulcers and opacities within 3 months, while corneas with Implant 2 (based on PEG-diacrylamide) remained clear at 6 months. They also exhibited normal numbers of epithelial cell layers, without any immune cell infiltration, inflammation, oedema or neovascularisation at post-operative 6 month. Morphological studies showed transient epithelial layer thinning over the hydrogel inserted area and elevated keratocyte activity at 3 months; however, the epithelium thickness and keratocyte morphology were improved at 6 months. Implant 2 exhibited superior in vivo biocompatibility and higher optical clarity than Implant 1. PEG-diacrylamide-based IPN hydrogel is therefore a potential candidate for corneal inlays to correct refractive error. © 2013 The Author(s).
Source Title: Journal of Materials Science: Materials in Medicine
ISSN: 09574530
DOI: 10.1007/s10856-012-4848-3
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