FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes

Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M113.504845

Title:	FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes
Authors:	Singh, B.K. Sinha, R.A. Zhou, J. Xie, S.Y. You, S.-H. Gauthier, K. Yen, P.M.
Issue Date:	18-Oct-2013
Citation:	Singh, B.K., Sinha, R.A., Zhou, J., Xie, S.Y., You, S.-H., Gauthier, K., Yen, P.M. (2013-10-18). FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. Journal of Biological Chemistry 288 (42) : 30365-30372. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.504845
Abstract:	Background: Thyroid hormone (TH) is known to induce transcription of hepatic gluconeogenic genes. Results: TH stimulates FoxO1 deacetylation to increase PCK1 and G6PC transcription. Conclusion: FoxO1 deacetylation by SirT1 is crucial for TH induction of its target genes, PCK1 and G6PC. Significance: This study demonstrates a novel role of FoxO1 in TH-mediated transcription that may explain some of the pleiotropic actions by TH. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title:	Journal of Biological Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/110088
ISSN:	00219258
DOI:	10.1074/jbc.M113.504845
Appears in Collections:	Staff Publications

There are no files associated with this item.

Check