Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M113.504845
Title: FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes
Authors: Singh, B.K.
Sinha, R.A.
Zhou, J. 
Xie, S.Y.
You, S.-H.
Gauthier, K.
Yen, P.M.
Issue Date: 18-Oct-2013
Citation: Singh, B.K., Sinha, R.A., Zhou, J., Xie, S.Y., You, S.-H., Gauthier, K., Yen, P.M. (2013-10-18). FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. Journal of Biological Chemistry 288 (42) : 30365-30372. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.504845
Abstract: Background: Thyroid hormone (TH) is known to induce transcription of hepatic gluconeogenic genes. Results: TH stimulates FoxO1 deacetylation to increase PCK1 and G6PC transcription. Conclusion: FoxO1 deacetylation by SirT1 is crucial for TH induction of its target genes, PCK1 and G6PC. Significance: This study demonstrates a novel role of FoxO1 in TH-mediated transcription that may explain some of the pleiotropic actions by TH. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title: Journal of Biological Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/110088
ISSN: 00219258
DOI: 10.1074/jbc.M113.504845
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