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|Title:||FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes|
|Source:||Singh, B.K., Sinha, R.A., Zhou, J., Xie, S.Y., You, S.-H., Gauthier, K., Yen, P.M. (2013-10-18). FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. Journal of Biological Chemistry 288 (42) : 30365-30372. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.504845|
|Abstract:||Background: Thyroid hormone (TH) is known to induce transcription of hepatic gluconeogenic genes. Results: TH stimulates FoxO1 deacetylation to increase PCK1 and G6PC transcription. Conclusion: FoxO1 deacetylation by SirT1 is crucial for TH induction of its target genes, PCK1 and G6PC. Significance: This study demonstrates a novel role of FoxO1 in TH-mediated transcription that may explain some of the pleiotropic actions by TH. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.|
|Source Title:||Journal of Biological Chemistry|
|Appears in Collections:||Staff Publications|
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