Please use this identifier to cite or link to this item:
|Title:||FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes|
|Citation:||Singh, B.K., Sinha, R.A., Zhou, J., Xie, S.Y., You, S.-H., Gauthier, K., Yen, P.M. (2013-10-18). FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. Journal of Biological Chemistry 288 (42) : 30365-30372. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.504845|
|Abstract:||Background: Thyroid hormone (TH) is known to induce transcription of hepatic gluconeogenic genes. Results: TH stimulates FoxO1 deacetylation to increase PCK1 and G6PC transcription. Conclusion: FoxO1 deacetylation by SirT1 is crucial for TH induction of its target genes, PCK1 and G6PC. Significance: This study demonstrates a novel role of FoxO1 in TH-mediated transcription that may explain some of the pleiotropic actions by TH. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.|
|Source Title:||Journal of Biological Chemistry|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 21, 2018
WEB OF SCIENCETM
checked on Jun 6, 2018
checked on Jun 22, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.