Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.11-8808
Title: Femtosecond lenticule extraction (FLEx): Clinical results, interface evaluation, and intraocular pressure variation
Authors: Ang, M.
Chaurasia, S.S.
Angunawela, R.I.
Poh, R.
Riau, A.
Tan, D.
Mehta, J.S. 
Issue Date: Mar-2012
Citation: Ang, M., Chaurasia, S.S., Angunawela, R.I., Poh, R., Riau, A., Tan, D., Mehta, J.S. (2012-03). Femtosecond lenticule extraction (FLEx): Clinical results, interface evaluation, and intraocular pressure variation. Investigative Ophthalmology and Visual Science 53 (3) : 1414-1421. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.11-8808
Abstract: PURPOSE. To characterize the clinical profile of femtosecond lenticule extraction (FLEx) correlated with ultrastructural analysis of the corneal interface and in vivo real-time intraocular pressure (IOP). METHODS. Prospective clinical case series with experimental studies; consecutive patients underwent FLEx at a single tertiary center over 10 months with postsurgical follow-up of 3 months. The patients were divided into three groups according to spherical equivalence (SE) (A, < -5.0 diopters [D]; B, ≥ -5.00 D and < -9.00 D; and C, ≥ -9.0 D). Twelve human cadaveric eyes analyzed using scanning electron microscopy after receiving FLEx; 40 rabbit eyes received FLEx with in vivo IOP measurements. The main outcome measures were refractive outcomes from study subjects; with corneal interface and IOP in experimental studies. RESULTS. Thirty-three subjects (22 females, 66.7%) underwent FLEx in both eyes (66 eyes). Mean age was 32 years (range, 21 to 46 years). Preoperative mean SE was -5.77 ± 2.04 D with astigmatism of -1.03 ± 0.72 D. There was a slight hyperopic shift (mean SE 0.14 ± 0.53 D); 94% achieved uncorrected visual acuity ≥20/25 3 months postoperatively. Refractive stability was achieved within 1 month (P < 0.001). Ultrastructurally, the smoothness of the corneal interface was independent of ablation depth (mean irregularity scores A, B, C: 8.8 ± 0.6, 10.3 ± 0.4, 8.7 ± 0.6, respectively; P = 0.88). The increase in IOP during FLEx was similar to that in femtosecond (FS)-LASIK, albeit a twofold duration of raised IOP in FLEx (P < 0.001). CONCLUSIONS. These results suggest that FLEx is predictable and effective in treating myopia and myopic astigmatism. Experimental studies support the early clinical results and safety of this procedure. © 2012 The Association for Research in Vision and Ophthalmology, Inc.
Source Title: Investigative Ophthalmology and Visual Science
URI: http://scholarbank.nus.edu.sg/handle/10635/110081
ISSN: 01460404
DOI: 10.1167/iovs.11-8808
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

57
checked on Jul 17, 2018

WEB OF SCIENCETM
Citations

54
checked on Jun 26, 2018

Page view(s)

29
checked on May 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.