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https://doi.org/10.1093/rheumatology/kes055
| Title: | Evaluation of a new multi-parallel line immunoassay for systemic sclerosis-associated antibodies in an Asian population | Authors: | Low, A.H.L. Wong, S. Thumboo, J. Ng, S.C. Lim, J.Y. Ng, X. Earnest, A. Fong, K.Y. |
Keywords: | Autoantigens and autoantibodies Biomarkers Immunological techniques Laboratory diagnosis Scleroderma and related disorders |
Issue Date: | Aug-2012 | Citation: | Low, A.H.L., Wong, S., Thumboo, J., Ng, S.C., Lim, J.Y., Ng, X., Earnest, A., Fong, K.Y. (2012-08). Evaluation of a new multi-parallel line immunoassay for systemic sclerosis-associated antibodies in an Asian population. Rheumatology (United Kingdom) 51 (8) : 1465-1470. ScholarBank@NUS Repository. https://doi.org/10.1093/rheumatology/kes055 | Abstract: | Objectives. To compare the SSc-line immunoassay (LIA) with conventional techniques of antibody detection, to evaluate its diagnostic utility and to describe clinical associations of antibodies in Asian SSc patients. Methods. Stored sera from patients with SSc (n = 68), SLE (n = 49), OA (n = 41) and normal controls (NCs, n = 32) were evaluated. Cohen's κ and Bland-Altman plots were used to evaluate agreement. Results. There was good agreement between LIA and ELISA for anti-Scl-70 (κ = 0.97), anti-CENPA (κ = 0.83), anti-CENPB (κ = 0.96) and anti-PmScl100 (κ = 1.00) (5.48-8.22% of values outside the 95% limits of agreement using Bland-Altman plots), and between LIA and IIF for anti-CENPA (κ = 0.81) and anti-CENPB (κ = 0.77) (P | Source Title: | Rheumatology (United Kingdom) | URI: | http://scholarbank.nus.edu.sg/handle/10635/110068 | ISSN: | 14620324 | DOI: | 10.1093/rheumatology/kes055 |
| Appears in Collections: | Staff Publications |
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