Please use this identifier to cite or link to this item: https://doi.org/10.1089/jwh.2012.3479
Title: Do menopausal status and use of hormone therapy affect antidepressant treatment response? Findings from the sequenced treatment alternatives to relieve depression (STAR*D) study
Authors: Kornstein, S.G.
Toups, M.
Rush, A.J. 
Wisniewski, S.R.
Thase, M.E.
Luther, J.
Warden, D.
Fava, M.
Trivedi, M.H.
Issue Date: 1-Feb-2013
Citation: Kornstein, S.G., Toups, M., Rush, A.J., Wisniewski, S.R., Thase, M.E., Luther, J., Warden, D., Fava, M., Trivedi, M.H. (2013-02-01). Do menopausal status and use of hormone therapy affect antidepressant treatment response? Findings from the sequenced treatment alternatives to relieve depression (STAR*D) study. Journal of Women's Health 22 (2) : 121-131. ScholarBank@NUS Repository. https://doi.org/10.1089/jwh.2012.3479
Abstract: Background: Menopausal status and use of hormonal contraception or menopausal hormone therapy (HT) may affect treatment response to selective serotonin reuptake inhibitors (SSRIs). This report evaluates whether menopausal status and use of hormonal contraceptives or menopausal HT affect outcome in women treated with citalopram. Methods: In the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, 896 premenopausal and 544 postmenopausal women were treated with citalopram for 12-14 weeks. Baseline demographic and clinical characteristics were used in adjusted analysis of the effect of menopausal status and use of hormonal contraceptives or menopausal HT on outcomes. Remission was defined as final Hamilton Rating Scale for Depression-17 (HRSD17) ≤7 or Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR16) score ≤5 and response as ≥50% decrease from the baseline QIDS-SR16 score. Results: Premenopausal and postmenopausal women differed in multiple clinical and demographic baseline variables but did not differ in response or remission rates. Premenopausal women taking hormonal contraceptives had significantly greater unadjusted remission rates on the HRSD17 and the QIDS-SR 16 than women not taking contraception. Response and remission rates were not different between postmenopausal women taking vs. not taking HT. Adjusted results showed no significant difference in any outcome measure across menopause status in women who were not taking contraception/HT. There were no significant differences in adjusted results across HT status in premenopausal or postmenopausal women. Conclusions: In this study, citalopram treatment outcome was not affected by menopausal status. Hormonal contraceptives and HT also did not affect probability of good outcome. © Copyright 2013, Mary Ann Liebert, Inc.
Source Title: Journal of Women's Health
URI: http://scholarbank.nus.edu.sg/handle/10635/110032
ISSN: 15409996
DOI: 10.1089/jwh.2012.3479
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