Please use this identifier to cite or link to this item: https://doi.org/10.1017/S1461145711001660
Title: Correlates and outcomes of depressed out-patients with greater and fewer anxious symptoms: A CO-MED report
Authors: Chan, H.N.
John Rush, A. 
Nierenberg, A.A.
Trivedi, M.
Wisniewski, S.R.
Balasubramani, G.K.
Friedman, E.S.
Gaynes, B.N.
Davis, L.
Morris, D.
Fava, M.
Keywords: Anxiety
depression
outcomes
treatment prediction
Issue Date: Nov-2012
Source: Chan, H.N., John Rush, A., Nierenberg, A.A., Trivedi, M., Wisniewski, S.R., Balasubramani, G.K., Friedman, E.S., Gaynes, B.N., Davis, L., Morris, D., Fava, M. (2012-11). Correlates and outcomes of depressed out-patients with greater and fewer anxious symptoms: A CO-MED report. International Journal of Neuropsychopharmacology 15 (10) : 1387-1399. ScholarBank@NUS Repository. https://doi.org/10.1017/S1461145711001660
Abstract: The objective of this paper was to determine whether the presence of more vs. fewer anxious symptom features, at baseline, are associated with other clinical features and treatment outcomes in out-patients with major depressive disorder (MDD). This single-blind, randomized trial enrolled 665 MDD out-patients to compare the efficacy of two antidepressant medication combinations against escitalopram after 12-wk acute treatment and follow-up (total 28 wk). The sample was divided into those with greater (vs. fewer) anxiety features using the anxiety/somatization subscale of the baseline 17-item Hamilton Rating Scale for Depression. Baseline sociodemographic and clinical features, treatment features and outcomes compared these two groups. Overall, 74.7% of participants met the threshold for anxious features. They were more likely to be female, have other concurrent anxiety disorders, more severe depression, more lethargic and melancholic features and poorer cognitive and physical functioning, quality of life and work and social adjustment. In acute treatment, participants with anxious features received comparatively higher doses of mirtazapine and venlafaxine and reported more side-effects. The groups with and without anxious features did not differ in treatment outcomes and side-effect burden. Despite being associated with a distinct clinical profile, baseline anxious features were not clinically useful in predicting acute treatment outcomes or differential treatment response. © 2011 CINP.
Source Title: International Journal of Neuropsychopharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/109992
ISSN: 14611457
DOI: 10.1017/S1461145711001660
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Feb 14, 2018

WEB OF SCIENCETM
Citations

12
checked on Feb 14, 2018

Page view(s)

20
checked on Feb 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.