Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0014687
Title: Aberrant DNA methylation of matrix remodeling and cell adhesion related genes in pterygium
Authors: Riau, A.K.
Wong, T.T.
Finger, S.N.
Chaurasia, S.S.
Hou, A.H.
Chen, S.
Yu, S.J.
Tong, L. 
Issue Date: 2011
Citation: Riau, A.K., Wong, T.T., Finger, S.N., Chaurasia, S.S., Hou, A.H., Chen, S., Yu, S.J., Tong, L. (2011). Aberrant DNA methylation of matrix remodeling and cell adhesion related genes in pterygium. PLoS ONE 6 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0014687
Abstract: Background: Pterygium is a common ocular surface disease characterized by abnormal epithelial and fibrovascular proliferation, invasion, and matrix remodeling. This lesion, which migrates from the periphery to the center of the cornea, impairs vision and causes considerable irritation. The mechanism of pterygium formation remains ambiguous, and current treatment is solely surgical excision, with a significant risk of recurrence after surgery. Here, we investigate the role of methylation in DNA sequences that regulate matrix remodeling and cell adhesion in pterygium formation.Methodology/Principal Findings: Pterygium and uninvolved conjunctiva samples were obtained from the same eye of patients undergoing surgery. The EpiTYPER Sequenom technology, based on differential base cleavage and bisulfite sequencing was used to evaluate the extent of methylation of 29 matrix and adhesion related genes. In pterygium, three CpG sites at -268, -32 and -29 bp upstream of transglutaminase 2 (TGM-2) transcription initiation were significantly hypermethylated (p
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/109906
ISSN: 19326203
DOI: 10.1371/journal.pone.0014687
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

24
checked on May 21, 2018

WEB OF SCIENCETM
Citations

20
checked on May 1, 2018

Page view(s)

28
checked on May 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.