Please use this identifier to cite or link to this item: https://doi.org/10.1042/BSR20100136
Title: Multifaceted link between cancer and inflammation
Authors: Sethi, G.
Shanmugam, M.K. 
Ramachandran, L.
Kumar, A.P. 
Tergaonkar, V.
Keywords: Activator protein 1 (AP-1)
Hypoxia-inducible factor 1α (HIF-1α)
Matrix metalloproteinase (MMP)
Nuclear factor κB (NF-κB)
Oncogene
Signal transducer and activator of transcription 3 (STAT3)
Issue Date: Feb-2012
Citation: Sethi, G., Shanmugam, M.K., Ramachandran, L., Kumar, A.P., Tergaonkar, V. (2012-02). Multifaceted link between cancer and inflammation. Bioscience Reports 32 (1) : 1-15. ScholarBank@NUS Repository. https://doi.org/10.1042/BSR20100136
Abstract: Increasing evidence from epidemiological, preclinical and clinical studies suggests that dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments including cancer. The molecular mechanism(s) by which chronic inflammation drives cancer initiation and promotion include increased production of pro-inflammatory mediators, such as cytokines, chemokines, reactive oxygen intermediates, increased expression of oncogenes, COX-2 (cyclo-oxygenase-2), 5-LOX (5-lipoxygenase) and MMPs (matrix metalloproteinases), and pro-inflammatory transcription factors such as NF-κB (nuclear factor κB), STAT3 (signal transducer and activator of transcription 3), AP-1 (activator protein 1) and HIF-1α (hypoxia-inducible factor 1α) that mediate tumour cell proliferation, transformation, metastasis, survival, invasion, angiogenesis, chemoresistance and radioresistance. These inflammation-associated molecules are activated by a number of environmental and lifestyle-related factors including infectious agents, tobacco, stress, diet, obesity and alcohol, which together are thought to drive as much as 90% of all cancers. The present review will focus primarily on the role of various inflammatory intermediates responsible for tumour initiation and progression, and discuss in detail the critical link between inflammation and cancer.
Source Title: Bioscience Reports
URI: http://scholarbank.nus.edu.sg/handle/10635/109852
ISSN: 01448463
DOI: 10.1042/BSR20100136
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2012-Multifaceted_link_between_cancer_inflammation-published.pdf392.17 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

155
checked on Jun 18, 2018

WEB OF SCIENCETM
Citations

134
checked on Jun 11, 2018

Page view(s)

88
checked on Jun 22, 2018

Download(s)

93
checked on Jun 22, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.