Please use this identifier to cite or link to this item:
|Title:||Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: A novel approach for controlling status epilepticus|
|Authors:||Tang, F.R. |
|Keywords:||Group I metabotropic glutamate receptor|
|Citation:||Tang, F.R., Chen, P.M., Tang, Y.C., Tsai, M.C., Lee, W.L. (2007-12). Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: A novel approach for controlling status epilepticus. Neuropharmacology 53 (7) : 821-831. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuropharm.2007.08.012|
|Abstract:||By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2 h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200 mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200 mg/kg), SIB1893 (from 25 to 100 mg/kg), MPEP (from 25 to 100 mg/kg) injected at 1 or 2 h during PISE were ineffective in controlling status epilepticus (SE). However, when administered at 1 h during PISE, MPEP at 200 mg/kg, combination of MPEP (200 mg/kg) with MK801 (0.1 mg/kg) or with MK801 (0.1 mg/kg) and diazepam (0.5 mg/kg), combination of SIB1893 (200 mg/kg) with MK801 (0.1 mg/kg) could effectively control behavioral SE, and were neuroprotective. In particular, the combination of MPEP with MK801 and diazepam could stop both behavioral SE and electrical SE (under EEG monitoring) within a few minutes after the administration. HPLC study showed that a high level of MPEP was maintained in the blood and its metabolism rate was slow in experimental mice with PISE. We therefore concluded that the combination of MPEP (200 mg/kg) with MK801 (0.1 mg/kg) and diazepam (0.5 mg/kg) could effectively stop SE and its subsequent neuronal loss in the hippocampus when administered 1 h during PISE. It may provide a new approach to effectively control intractable SE. © 2007 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 17, 2018
WEB OF SCIENCETM
checked on Sep 17, 2018
checked on Sep 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.