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|Title:||Reactive oxygen species-mediated regulation of the Na+- H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers|
Na+/H+ exchanger NHE-1
|Citation:||Akram, S., Teong, H.F.C., Fliegel, L., Pervaiz, S., Clément, M.V. (2006-04). Reactive oxygen species-mediated regulation of the Na+- H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers. Cell Death and Differentiation 13 (4) : 628-641. ScholarBank@NUS Repository.|
|Abstract:||We have previously demonstrated that a slight increase in intracellular superoxide (O2 •-) anion confers resistance to death stimuli. Using pharmacological and molecular approaches to manipulate intracellular O2 •-, here we report that an increase in intracellular O2 •- anion induces Na+/H+ exchanger 1 (NHE-1) gene promoter activity resulting in increased NHE-1 protein expression, which strongly correlates with the resistance of cells to death stimuli. In contrast, exposure to exogenous hydrogen peroxide suppressed NHE-1 promoter activity and gene expression, and increased cell sensitivity to death triggers. Furthermore, the increase in cell sensitivity to death upon downregulation of NHE-1 gene expression correlates with reduced capacity of cells to recover from an acid load, while survival upon overexpression of NHE-1 appears independent of its pump activity. These findings indicate that NHE-1 is a redox-regulated gene, and provide a novel intracellular target for the redox control of cell death sensitivity. © 2006 Nature Publishing Group. All rights reserved.|
|Source Title:||Cell Death and Differentiation|
|Appears in Collections:||Staff Publications|
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