Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis

Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M113.475798

Title:	Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis
Authors:	Zheng, J. Rubin, E.J. Bifani, P. Mathys, V. Lim, V. Au, M. Jang, J. Nam, J. Dick, T. Walker, J.R. Pethe, K. Camacho, L.R.
Issue Date:	9-Aug-2013
Citation:	Zheng, J., Rubin, E.J., Bifani, P., Mathys, V., Lim, V., Au, M., Jang, J., Nam, J., Dick, T., Walker, J.R., Pethe, K., Camacho, L.R. (2013-08-09). Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis. Journal of Biological Chemistry 288 (32) : 23447-23456. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.475798
Abstract:	Background: PAS is an antimycobacterial whose mechanism(s) of action remains elusive. Results: PAS is incorporated into the folate pathway by DHPS-DHFS, generating an anti-metabolite. DHFS and RibD are associated with PAS resistance. Conclusion: Hydroxyl dihydrofolate inhibits DHFR. folC and ribD are drug target genes for identification of clinical PAS resistance. Significance: Metabolite analog incorporation into essential biosynthetic pathways is promising for developing antibacterials. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title:	Journal of Biological Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/109505
ISSN:	00219258
DOI:	10.1074/jbc.M113.475798
Appears in Collections:	Staff Publications

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