Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/109486
Title: NHE-1: A promising target for novel anti-cancer therapeutics
Authors: Loo, S.Y.
Chang, M.K.X.
Chua, C.S.H.
Kumar, A.P. 
Pervaiz, S.
Clement, M.V. 
Keywords: Cancer therapy
NHE1
Issue Date: Apr-2012
Citation: Loo, S.Y.,Chang, M.K.X.,Chua, C.S.H.,Kumar, A.P.,Pervaiz, S.,Clement, M.V. (2012-04). NHE-1: A promising target for novel anti-cancer therapeutics. Current Pharmaceutical Design 18 (10) : 1372-1382. ScholarBank@NUS Repository.
Abstract: Among the many factors involved in the maintenance of homeostatic growth is the tight regulation of cellular pH. Intracellular pH of normal cells is maintained within a physiological range thanks to the activity of a number of pH regulators that respond to the acid-base shifts associated with normal cellular metabolic processes. Interestingly, there is a preponderance of evidence that dysregulation of intracellular pH is associated with processes that favor cell transformation such as cell cycle progression, enhanced proliferation, insensitivity to growth inhibitory stimuli, resistance to apoptosis, genomic instability and angiogenesis. Among the strategies employed by the cells to regulate intracellular pH, the Na+/H+ exchanger 1 (NHE1) protein from the Na+/H+ exchanger (NHE) family has been directly associated with cellular transformation, invasion and metastasis. These observations have heightened the interest in NHE1 as a promising novel drug target for more effective and selective anti-cancer therapeutics. Here we present a review of the basic biology of this remarkable protein and present evidence to support targeting NHE1 as a potential anti-cancer strategy. © 2012 Bentham Science Publishers.
Source Title: Current Pharmaceutical Design
URI: http://scholarbank.nus.edu.sg/handle/10635/109486
ISSN: 13816128
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

46
checked on Nov 2, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.