Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q
Xu, H. Cheng, R. Juo, S.-H. Liu, J. Loth, J.E. Endicott, J. Gilliam, C. Baron, M.
Cheng, R.
Juo, S.-H.
Liu, J.
Loth, J.E.
Endicott, J.
Gilliam, C.
Baron, M.
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Alternative Title
Abstract
Genomewide scans of bipolar disorder (BP) have not produced consistent linkage findings. Follow-up studies using enlarged samples and enhanced marker density can bolster or refute claims of linkage and pave the way to gene discovery. We conducted linkage and association analyses, using a ∼3-cM density map of 10 candidate regions, in a large BP pedigree sample (865 individuals from 56 pedigrees). The candidate regions were identified in a previous 10-cM genome-wide scan using a subset of this sample (373 individuals from 40 pedigrees). The present sample consists of the expanded original pedigrees ("core" pedigrees) and 16 additional pedigrees. We obtained experiment-wide significant linkage on chromosome 7q34 (LOD score 3.53, P
Keywords
Bipolar, Follow-up, Genome scan, Linkage
Source Title
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Publisher
Series/Report No.
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Date
2011-03
DOI
10.1002/ajmg.b.31151
Type
Article