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|Title:||Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q||Authors:||Xu, H.
|Issue Date:||Mar-2011||Citation:||Xu, H., Cheng, R., Juo, S.-H., Liu, J., Loth, J.E., Endicott, J., Gilliam, C., Baron, M. (2011-03). Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 156 (2) : 168-176. ScholarBank@NUS Repository. https://doi.org/10.1002/ajmg.b.31151||Abstract:||Genomewide scans of bipolar disorder (BP) have not produced consistent linkage findings. Follow-up studies using enlarged samples and enhanced marker density can bolster or refute claims of linkage and pave the way to gene discovery. We conducted linkage and association analyses, using a ∼3-cM density map of 10 candidate regions, in a large BP pedigree sample (865 individuals from 56 pedigrees). The candidate regions were identified in a previous 10-cM genome-wide scan using a subset of this sample (373 individuals from 40 pedigrees). The present sample consists of the expanded original pedigrees ("core" pedigrees) and 16 additional pedigrees. We obtained experiment-wide significant linkage on chromosome 7q34 (LOD score 3.53, P||Source Title:||American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics||URI:||http://scholarbank.nus.edu.sg/handle/10635/109344||ISSN:||15524841||DOI:||10.1002/ajmg.b.31151|
|Appears in Collections:||Staff Publications|
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