Engagement of the small gtpase rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome

Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M114.548321

Title:	Engagement of the small gtpase rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome
Authors:	Chua, C.E.L. Tang, B.L.
Issue Date:	2014
Citation:	Chua, C.E.L., Tang, B.L. (2014). Engagement of the small gtpase rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome. Journal of Biological Chemistry 289 (18) : 12375-12389. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M114.548321
Abstract:	Background: Rab31 is a member of the Rab5 subfamily of Rab GTPases. Results: Manipulation of Rab31 and interacting partners affects trafficking of the EGF receptor (EGFR) to the late endosome. Conclusion: Rab31, with its regulator and effector, plays an important role in the trafficking of the EGFR from the early to the late endosome. Significance: Evidence is provided for Rab31 being a key regulator of endocytic traffic of the EGFR. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title:	Journal of Biological Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/109325
ISSN:	1083351X
DOI:	10.1074/jbc.M114.548321
Appears in Collections:	Staff Publications

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