Please use this identifier to cite or link to this item:
|Title:||Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels|
|Citation:||Navakkode, S., Sajikumar, S., Korte, M., Soong, T.W. (2012-07). Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels. Learning and Memory 19 (7) : 294-299. ScholarBank@NUS Repository. https://doi.org/10.1101/lm.026203.112|
|Abstract:||The dopaminergic modulation of long-term potentiation (LTP) has been studied well, but the mechanism by which dopamine induces LTP (DA-LTP) in CA1 pyramidal neurons is unknown. Here, we report that DA-LTP in basal dendrites is dependent while in apical dendrites it is independent of activation of L-type voltage-gated calcium channels (VDCC). Activation via NMDAR is critical for the induction of DA-LTP in both apical and basal dendrites, but only BDNF is required for the induction and maintenance of DA-LTP in apical dendrites. We report that dopaminergic modulation of LTP is lamina-specific at the Schaffer collateral/commissural synapses in the CA1 region. © 2012 Cold Spring Harbor Laboratory Press.|
|Source Title:||Learning and Memory|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 16, 2018
WEB OF SCIENCETM
checked on May 30, 2018
checked on Jun 8, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.