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|Title:||Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels|
|Citation:||Navakkode, S., Sajikumar, S., Korte, M., Soong, T.W. (2012-07). Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels. Learning and Memory 19 (7) : 294-299. ScholarBank@NUS Repository. https://doi.org/10.1101/lm.026203.112|
|Abstract:||The dopaminergic modulation of long-term potentiation (LTP) has been studied well, but the mechanism by which dopamine induces LTP (DA-LTP) in CA1 pyramidal neurons is unknown. Here, we report that DA-LTP in basal dendrites is dependent while in apical dendrites it is independent of activation of L-type voltage-gated calcium channels (VDCC). Activation via NMDAR is critical for the induction of DA-LTP in both apical and basal dendrites, but only BDNF is required for the induction and maintenance of DA-LTP in apical dendrites. We report that dopaminergic modulation of LTP is lamina-specific at the Schaffer collateral/commissural synapses in the CA1 region. © 2012 Cold Spring Harbor Laboratory Press.|
|Source Title:||Learning and Memory|
|Appears in Collections:||Staff Publications|
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