Please use this identifier to cite or link to this item:
|Title:||Correlation between retinal oscillatory potentials and retinal vascular caliber in type 2 diabetes|
|Citation:||Luu, C.D., Szental, J.A., Lee, S.-Y., Lavanya, R., Wong, T.Y. (2010-01). Correlation between retinal oscillatory potentials and retinal vascular caliber in type 2 diabetes. Investigative Ophthalmology and Visual Science 51 (1) : 482-486. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.09-4069|
|Abstract:||PURPOSE. To assess retinal function in individuals with type 2 diabetes with no retinopathy or nonproliferative diabetic retinopathy (NPDR) and determine the relationship between retinal function and retinal vascular caliber. METHODS. A full-field electroretinogram (ERG) and retinal vascular caliber measurements were performed in subjects with nonproliferative diabetic retinopathy (NPDR, n = 10), diabetic subjects without retinopathy (no-DR, n = 18), and normal control subjects (n = 18). The response amplitudes and implicit times of scotopic and photopic ERG and the retinal arteriolar and venular calibers were compared among the study groups. The relationships between ERG parameters and retinal vascular calibers were determined. RESULTS. There were statistically significant differences between diabetic (no-DR and NPDR groups) and control subjects in the amplitudes and implicit times of rod-derived ERG responses, but not in the cone-derived ERG responses. All the oscillatory potential (OP) components (OP1-OP4) were significantly reduced in amplitude and increased in implicit time in the no-DR and NPDR groups. No significant difference was found in any of the ERG parameters between the no-DR and NPDR groups. Of all the ERG parameters examined, only OP4 amplitude correlated significantly with the retinal arteriolar caliber (r = -0.556, P = 0.006). None of the OP components correlated significantly with retinal venular caliber. CONCLUSIONS. Significant retinal dysfunction was demonstrated in all diabetic patients, even in those without clinically detectable retinopathy, with the rod system being predominantly affected. OP4 amplitude correlates with retinal arteriolar caliber in diabetic patients, suggesting a correlation between retinal neuronal dysfunction and microvasculature changes. © Association for Research in Vision and Ophthalmology.|
|Source Title:||Investigative Ophthalmology and Visual Science|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 12, 2018
WEB OF SCIENCETM
checked on Sep 12, 2018
checked on Sep 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.