Please use this identifier to cite or link to this item: https://doi.org/10.1001/jamaophthalmol.2013.5024
Title: Challenges in elucidating the genetics of diabetic retinopathy
Authors: Kuo, J.Z.
Wong, T.Y. 
Rotter, J.I.
Wiggs, J.L.
Issue Date: Jan-2014
Citation: Kuo, J.Z., Wong, T.Y., Rotter, J.I., Wiggs, J.L. (2014-01). Challenges in elucidating the genetics of diabetic retinopathy. JAMA Ophthalmology 132 (1) : 96-107. ScholarBank@NUS Repository. https://doi.org/10.1001/jamaophthalmol.2013.5024
Abstract: Importance: In the past decade, significant progress in genomic medicine and technologic developments has revolutionized our approach to common complex disorders in many areas of medicine, including ophthalmology. A disorder that still needs major genetic progress is diabetic retinopathy (DR), one of the leading causes of blindness in adults. Objective: To perform a literature review, present the current findings, and highlight some key challenges in DR genetics. Design, setting, and participants: We performed a thorough literature review of the genetic factors for DR, including heritability scores, twin studies, family studies, candidate gene studies, linkage studies, and genome-wide association studies (GWASs). Main outcome measures: Environmental and genetic factors for DR. Results: Although there is clear demonstration of a genetic contribution in the development and progression of DR, the identification of susceptibility loci through candidate gene approaches, linkage studies, and GWASs is still in its infancy. The greatest obstacles remain a lack of power because of small sample size of available studies and a lack of phenotype standardization. Conclusions and relevance: The field of DR genetics is still in its infancy and is a challenge because of the complexity of the disease. This review outlines some strategies and lessons for future investigation to improve our understanding of this complex genetic disorder. Copyright © 2014 American Medical Association.
Source Title: JAMA Ophthalmology
URI: http://scholarbank.nus.edu.sg/handle/10635/109232
ISSN: 21686165
DOI: 10.1001/jamaophthalmol.2013.5024
Appears in Collections:Staff Publications

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