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https://doi.org/10.1038/gene.2012.25
| Title: | Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese | Authors: | Dunstan, S.J. Rockett, K.A. Quyen, N.T.N. Teo, Y.Y. Thai, C.Q. Hang, N.T. Jeffreys, A. Clark, T.G. Small, K.S. Simmons, C.P. Day, N. O'Riordan, S.E. Kwiatkowski, D.P. Farrar, J. Phu, N.H. Hien, T.T. |
Keywords: | genetic association ICAM1 IL17RC severe malaria SNP TNF |
Issue Date: | Sep-2012 | Citation: | Dunstan, S.J., Rockett, K.A., Quyen, N.T.N., Teo, Y.Y., Thai, C.Q., Hang, N.T., Jeffreys, A., Clark, T.G., Small, K.S., Simmons, C.P., Day, N., O'Riordan, S.E., Kwiatkowski, D.P., Farrar, J., Phu, N.H., Hien, T.T. (2012-09). Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese. Genes and Immunity 13 (6) : 503-508. ScholarBank@NUS Repository. https://doi.org/10.1038/gene.2012.25 | Abstract: | The genetic basis for susceptibility to malaria has been studied widely in African populations but less is known of the contribution of specific genetic variants in Asian populations. We genotyped 67 single-nucleotide polymorphisms (SNPs) in 1030 severe malaria cases and 2840 controls from Vietnam. After data quality control, genotyping data of 956 cases and 2350 controls were analysed for 65 SNPs (3 gender confirmation, 62 positioned in/near 42 malarial candidate genes). A total of 14 SNPs were monomorphic and 2 (rs8078340 and rs33950507) were not in Hardy-Weinberg equilibrium in controls (P | Source Title: | Genes and Immunity | URI: | http://scholarbank.nus.edu.sg/handle/10635/109085 | ISSN: | 14664879 | DOI: | 10.1038/gene.2012.25 |
| Appears in Collections: | Staff Publications |
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